Xintela publishes positive preclinical results from XSTEM treatment of ARDS
Results from Xintela’s preclinical study with XSTEM® for the treatment of ARDS (Acute Respiratory Distress Syndrome) have been published in the journal Respiratory Research. The results show that XSTEM has a therapeutic effect and provides more stable blood circulation, reduced lung tissue damage and reduced blood clotting compared to placebo.
Xintela has previously announced that the company’s stem cell product XSTEM was evaluated for the treatment of ARDS in a validated preclinical pig model that is clinically similar to the life-threatening lung complication in ARDS patients. The study, which was partly financed by Vinnova, was carried out in collaboration with Professor Sandra Lindstedt and her team at the Department of Thoracic Surgery, Skåne University Hospital in Lund. The results of this study have now been published in the international scientific journal Respiratory Research (https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-023-02459-6). The results show, among other things, that the animals treated with XSTEM have more stable blood circulation, less lung tissue damage and lower blood coagulation compared to the animals treated with placebo. No negative side effects were noted during the treatment.
ARDS is a form of acute severe lung failure that can occur as a result of, for example, pneumonia, sepsis or trauma. With this condition, the lung function collapses and the mortality is high. The is no effective treatment available.
“We are really pleased that the results from the study have now been reviewed and published in a very impactful journal. This means that XSTEM will get extra attention as a new treatment option for ARDS with the potential to improve the severe condition in ARDS patients, which can shorten intensive care time and reduce mortality. The results, showing both safety and efficacy, also provide strong support for continued clinical development”, says Xintela’s CEO Evy Lundgren-Åkerlund.